Juan Lu, PhD, MPH, MD
Associate Professor, Division of Epidemiology
One Capitol Square, 8th floor, suite 826
Phone: (804) 828-9786
- PhD - Virginia Commonwealth University, 2010
- MPH - Virginia Commonwealth University, 2001
- MD - Suzhou University, 1983
Outcomes and healthcare costs following traumatic brain injury, efficacy and effectiveness of intervention following traumatic brain injury, experimnetal and observational research designs in general, disparities in healthcare and related costs, sensitivity analysis and large database management.
CCTR 630, Clinical Trials: Design Implications:
The course is intended for the research scientist in training. The goal is to sharpen the methodologic skills in designing experimental studies for clinical investigators. The course addresses theoretical and practical methods in designing clinical trials with emphasis on design implications and development of individual study protocols. The course focuses on designing intervention studies to achieve research objectives by selecting appropriate study samples, end points and trial designs. Specific topics include efficacy versus effectiveness trials and critiquing clinical trial protocols, with emphasis on evaluating strengths and weaknesses of the trial design.
EPID 651, Intermediate Epidemiologic Methods
The course is intended as a second year epidemiology methods course for doctoral students in epidemiology and related disciplinarians. The goal is to sharpen the methodologic skills in designing and conducting epidemiologic studies. The course addresses theoretical and practical methods in designing epidemiologic studies with emphasis on cohort, cross sectional and case-control study designs. The course focuses on designing epidemiologic studies to achieve research objectives by minimizing bias in design, data analysis and implementations. Specific topics include bias analysis, propensity score matching and critiquing epidemiologic studies in strengths and limitations.
EPID 652 Advanced Epidemiologic Methods and Data Analysis
Covering data analysis sections for cohort studies, including Cox Proportional-Hazards Regression and Poisson Regression models.
CCTR 631, Adaptive Clinical Trials: Design Implications
The course provides an overview of the theoretical framework and key concepts of adaptive design methods in clinical trials. The design and implementation process are discussed through real-world examples. The feasibility, validity, integrity and efficiency of the trial designs are stressed through comparisons between traditional fixed and adaptive trials.
CCTR 691, Pragmatic Clinical Trials
The course provides an overview of the frameworks and characteristics of pragmatic trial designs. The design process and implications are discussed through various real-world examples. The internal and external validity of the clinical trials are stressed between the pragmatic and exploratory trial designs.
- Outstanding Teacher Award, Division of Epidemiology, Department of Family Medicine and Population Health, Virginia Commonwealth University, School of Medicine
- Outstanding Teacher Award in Ph.D. Program, Department of Family Medicine and Population Health, Virginia Commonwealth University, School of Medicine
- First place winner of Henry Stonnington Award for Review Articles, Journal of Brain Injury
- Guest professor, Department of Physical Medicine and Rehabilitation, Oslo University, Norway
- Exceptional Employment Award, Virginia Commonwealth University
- American Public Health Association
- The Society for Clinical Trials
- VCU CERSE Community
- Lu J, Britton E, Ferrance J, Rice E, Kuzel A, Dow A. Identifying Future High Cost Individuals within an Intermediate Cost Population. 2015 Qual Prim Care. 23(6):318-326.
- Lu J, Copolillo A, Gary KG, Ward J, Niemeier J, Lapane K. Randomized Controlled Trials in Adult Traumatic Brain Injury: Compliance to the CONSORT Statement, Review Archives of physical medicine and rehabilitation 2015 April Volume: 96 Issue: 4 Pg: 702-14 ISSN: 0003-9993 PMID: 25497515
- Lu. J, Roe C, Neimeier JP, Lapane KL, Juan Arango, Andelic N. Traumatic Brain Injury: Methodological Approaches to Estimate Health and Economic Outcomes Review J Neurotrauma. 2013 Dec 1;30(23):1925-33.
- Lu. J, Gary KW, Neimeier JP, Ward J, Lapane KL (2012) Randomized Controlled Trials in Adult Traumatic Brain Injury. Review Brain Injury: 26(13-14):1523-48 [PubMed]
- Lu J, Marmarou A, Lapane L (2011) Impact of GOS Misclassification and Ordinal Outcome Analysis on Traumatic Brain Injury Clinical Trials. J Neurotrauma: 20;29(5):719-26 [PubMed]
- Lu J, Marmarou A, Lapane K, Turf E, Wilson JT (2010) A Method for Reducing Misclassification in the extended Glasgow Outcome Score J Neurotrauma: 27(5):843-52. [PubMed]
- Maas AIR, Steyerberg EW, Marmarou A, McHugh GS, Lingsma HF, Butcher I, Lu J, Weir J, Roozenbeek B, Murray GD (2010) IMPACT Recommendations for Improving the Design and Analysis of Clinical Trials in Moderate to Severe Traumatic Brain Injury Neurotherapeutics: 7; 127-134 [PubMed]
- Lu J, Murray GD, Steyerberg EW, Butcher I, Taylor GS, Lingsma H, Mushkudiani NA, Murray GD, Maas AIR Marmarou A. (2008) Effects of Glasgow Outcome Scale Misclassification on Traumatic Brain Injury Clinical Trials. J Neurotrauma: 25: 641-651 [PubMed]
- Marmarou A, Lu J, Butcher I, Taylor GS, Mushkudiani NA, Murray GD, Steyerberg EW, Maas AIR. (2007) The IMPACT database on traumatic brain injury: design and description. J Neurotrauma: 24 (2), 239-250. [PubMed]
Traumatic Brain Injury
The traumatic brain injury (TBI) research program in the Division of Epidemiology focuses in three major areas: (1) to understand and evaluate outcome misclassification in, and develop methods to minimize its impact on TBI clinical trials; (2) to synthesize the evidence regarding the treatment of TBI and improve experimental study design in TBI research; and (3) to develop intervention programs for persons with chronic TBI and evaluate health and economic outcomes in such intervention programs.